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Overview

TCTC

In this consortium, we mainly focus on pancreatic, gastroesophageal, and biliary tract cancer treatment, including 1st line or 2nd line chemotherapy, immunotherapy, or target therapy. Our goals are:

  1. Collecting UGI cancer patients’ clinical data and specimens for the future of clinical trials and drug development.
  2. Searching new biomarkers for predicting UGI cancer patients’ outcome.
  3. To help new drugs of international pharmaceutical companies or generic drugs/new drugs of domestic pharmaceutical manufacturers proceeded clinical trials.
  4. To perform good design PI initiated clinical trials.

Strengths

TCTC

1. To advance early or late phase trials of adjuvant therapy, neoadjuvant therapy, salvage therapy, and surgery clinical trials.

2. To establish the SOPs for clinical informatics and specimen collection of pancreatic, gastroesophageal, and biliary tract cancers and developed the UGI big bio-databases for data management and visualization and thereby facilitate the clinical trials.

3. From improved chemotherapy to precision medicine, we are currently launching International Collaborative Research Programs aimed to develop novel therapeutic strategies based on targeted, gene-, nano-, cell-, and immuno-therapies or emerging medication, biomedical materials/modalities, or multimodal artificial intelligence, etc.

Major Achievements

TCTC

International Collaboration︰

  • We have performed more than 100 cancer clinical trials of international pharmaceutical companies. We have regular meetings with CROs from American, France, Switzerland, Denmark, Japan, and South Korea to make effective communication among PIs and hospital care team members.
  • The number of cases recruited in the NAPOLI-1 trial was the highest in the world, and two hospitals received FDA inspection (NCKUH and VGHTPE).
  • After facilitating the completions of clinical trials, we can increase the reputation of Taiwan in UGI cancers consortium in the world.
 

Economic Benefits:

  • With continued success of new drug clinical trials, our endeavor could reduce health insurance expenditures and reduce financial burdens.
  • We have conducted more than 30 early phase clinical trials sponsored by domestic pharmaceutical manufacturers. PIs are invited by sponsor to evaluate the feasibility of new drug programs every year.
  • We have assisted the completion of the third phase clinical trial (NAPOLI-1) which is the first new cancer drug approved by the US FDA in the history of new drug development in Taiwan.
 

Social Influence︰

  • Our endeavor can recruit patients (N>5600) receive new treatment in medical centers, and patients can receive comprehensive treatment and thereby obtain better medical care quality.
  • We can help patients to understand the different regimens in different hospitals to improve patients’ outcome after received suitable treatment regimens from trials. We also help patients to obtain compassionate treatment and thereby reduce their financial burden and stress.
  • Liposomal irinotecan (nal-IRI) plus 5-fluorouracil and leucovorin (5-FU/LV) is approved for patients with metastatic pancreatic cancer, which can significantly improve overall survival compared with 5-FU/LV alone (11.6 vs. 5.5 months), with approximately 10% of patients surviving beyond 20 months. This combination regimen has an acceptable safety profile and generally manageable AEs, while maintaining quality of life over time versus 5-FU/LV alone.

Consortium Highlights︰

  • We execute more than 50 global, 10 local, and 12 IIT clinical trials including new and continuation cases.
  • To create a clustering effect and engage more PIs or hospitals to join us via regularly hold UGI-TCTC meetings, consensus camps, or conferences every year, and invite domestic and foreign experts/scholars to conduct clinical practice or academic research exchanges and experience sharing with TCTC PIs and their research teams.
  • Our research results will be published in more than 10 international journals and at least 3 conference/symposium presentations every year.
 

Members

TCTC

National Cheng Kung University Hospital / Department of Surgery

National Cheng Kung University Hospital / Department of Oncology

National Cheng Kung University Hospital / Department of Oncology

Kaohsiung Medical University Chung-Ho Memorial Hospital / Department of Oncology

Taipei Veterans General Hospital / Department of Oncology

China Medical University Hospital / Department of Oncology

Kaohsiung Chang Gung Memorial Hospital/ Department of Oncology

National Cheng Kung University Hospital/Division of General Surgery

Linkou Chang Gung Memorial Hospital /Division of General Surgery

National Taiwan University Hospital / Department of Surgery

Linkou Chang Gung Memorial Hospital/ Department of Oncology

National Taiwan University Hospital/ Department of Oncology

National Institute of Cancer Research/ National Health Research Institutes

Taipei Veterans General Hospital/ Division of General Surgery

Contact Information

c-IRB

Shan Yan-Shen

Email:ysshan@mail.ncku.edu.tw

TEL:06-2353535 ext #3105